![]() ![]() The first hydroxylation, which occurs in the liver, converts vitamin D to 25-hydroxyvitamin D, also known as "calcidiol." The second hydroxylation occurs primarily in the kidney and forms the physiologically active 1,25-dihydroxyvitamin D, also known as "calcitriol". Vitamin D obtained from sun exposure, foods, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. ![]() It is also produced endogenously when ultraviolet (UV) rays from sunlight strike the skin and trigger vitamin D synthesis. Vitamin D (also referred to as "calciferol") is a fat-soluble vitamin that is naturally present in a few foods, added to others, and available as a dietary supplement. For a reader-friendly overview of Vitamin D, see our consumer fact sheet on Vitamin D.įor information on vitamin D and COVID-19, see Dietary Supplements in the Time of COVID-19. This is a fact sheet intended for health professionals. ![]()
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